잘 됩니다.

In [1]: import sys

In [2]: sys.argv[0]
Out[2]: '/home/allinux/workspace/lang/py36/bin/ipython'

In [3]: sys.argv[1]
Out[3]: '-i'

In [4]: sys.argv[1] = 'aaaaaaa'

In [5]: sys.argv[1]
Out[5]: 'aaaaaaa'